Contact Information
Address (Office) E12-3008  Hongjie Zhang
(Lab) N22-2031
Phone (Office) 8822 4518
(Lab) 8822 2732
Fax 8822 2314
Email HJZhang@umac.mo
Education
Ph.D. University of Tokushima, Tokushima, Japan
M.Sc. Zhengzhou University, Zhengzhou, China
B.Sc. Zhengzhou University, Zhengzhou, China
Positions
2015-present Assistant Professor, Faculty of Health Sciences, University of Macau
2011-2014 Instructor, Massachusetts General Hospital/Harvard Medical School, Boston, USA
2006-2011 Research fellow, Massachusetts General Hospital/Harvard Medical School, Boston, USA
2003-2006 Postdoctoral fellow, Albert Einstein College of Medicine, New York, USA
2003 Lecturer, University of Tokushima, Tokushima, Japan
Research Interests
The main research interest of our group is focused on the molecular mechanism of organ morphogenesis. Majority of human diseases are originated from internal organs. Understanding the molecular mechanism of organ formation and maintenance is fundamental to developmental biology and medicine. However, currently the process of organ morphogenesis is not possible to be examined in complex organisms in vivo. We use genetically tractable and structurally simple C. elegans as a model system, employing genetic, biochemical and functional genomics approaches to investigate how organs form and how the shape and size of organs are regulated and maintained.We are also interested in in vivo sphingolipid (SL) homeostatic network regulation. SLs are involved in a wide array of cellular processes and are affected in a variety of diseases ranging from diabetes to cancer, from neurodegenerative- to cardiovascular diseases. Yet, little is known about their roles in the development of these diseases and their potential to serve as drugs or treatment targets. We use the C. elegans model, with a simple set of conserved SLs, to delineate the SL homeostatic network and its regulation on the whole organism level and to explore the link between SL metabolites and the pathology of the diseases linked to defects in SL biosynthesis and metabolism.
Representative Publications
  • Zhang H.; Abraham N.; Khan L.; Gobel V. RNAi-based biosynthetic pathway screens to identify in vivo functions of non-nucleic acid–based metabolites such as lipids. Nature protocols 2015 Jun;10(6):939.
  • Hongjie Zhang, Ahlee Kim, Nessy Abraham, Liakot A. Khan and Verena Gobel, 2013. Vesicular sorting controls the polarity of expanding membranes in the C. elegans intestine. Worm, 2, 1-13.
  • Liakot A Khan, Hongjie Zhang, Nessy Abraham, John T. Fleming, David H. Hall, Matthew Buechner and Verena Gobel, 2013. Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux. Nature Cell Biology, 15, 143-156. (Featured as News & Views Article in the same journal.)
  • Hongjie Zhang, Ahlee Kim, Nessy Abraham, Liakot A. Khan, John T. Fleming and Verena Gobel, 2012. Clathrin and AP-1 mediate apical polarity and lumen formation in C. elegans tubulogenesis. Development, 139, 2071-2083.
  • Hongjie Zhang, Nessy Abraham, Liakot A. Khan, David H. Hall, John T. Fleming and Verena Gobel, 2011. Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis. Nature Cell Biology, 13, 1189-1201. (Featured as News & Views Article in the same journal, cited by Faculty of 1000 and highlighted as Editor’s Choice in Science.)
  • Hongjie Zhang and Scott Emmons, 2009. Regulation of the Caenorhabditis elegans posterior Hox gene egl-5 by microRNA and the polycomb-like gene sop-2. Dev Dyn. 238, 595-603.
  • Taro Mito, Chiharu Kobayashi, Isao Sarashina, Hongjie Zhang, Wakako Shinahara, Katsuyuki Miyawaki, Yohei Shinmyo, Hideyo Ohuchi and Sumihare Noji, 2007. even-skipped has gap-like, pair-rule-like, and segmental functions in the cricket Gryllus bimaculatus, a basal, intermediate germ insect (Orthoptera). Dev Biol 303, 202-213.
  • Taro Mito, Isao Sarashina, Hongjie Zhang, Akihiro Iwahashi, Haruko Okamoto, Katsuyuki Miyawaki, Yohei Shinmyo, Hideyo Ohuchi and Sumihare Noji, 2005. Non-canonical functions of hunchback in segment patterning of the intermediate germ cricket Gryllus bimaculatus. Development 132, 2069-2079.
  • Hongjie Zhang, Yohei Shinmyo, Taro Mito, Katsuyuki Miyawaki, Hideyo Ohuchi and Sumihare Noji, 2005. Expression pattern of homeotic genes Scr, Antp, Ubx and abd-A during embryogenesis of the cricket Gryllus bimaculatus. Gene Expr Patterns. 5, 491-502.
  • Katsuyuki Miyawaki, Taro Mito, Isao Srashina, Hongjie Zhang, Yohei Shinmyo, Hideyo Ohuchi and Sumihare Noji, 2004. Involvement of Wingless/Armadillo signaling in the posterior sequential segmentation in the cricket, Gryllus bimaculatus (Orthoptera), as revealed by RNAi analysis. Mech Dev. 121, 119-30.
  • Hongjie Zhang, Yohei Shinmyo, Ayumi Hirose, Taro Mito, Yoshiko Inoue, Hideyo Ohuchi, Thanasis G. Loukeris, Paul Eggleston, and Sumihare Noji, 2002. Extrachromosomal Transposition of the Transposable Element Minos Occurs in Embryos of the Cricket Gryllus bimaculatus, Development Growth & Differentiation, 44, 409-417.
  • Hongjie Zhang and Yoshihiro Ito, 2001. pH Control of Substances Permeation through a Porous Membrane Self-Assembled with Poly(Acrylic Acid) Loop Brush, Langmuir, 17, 8336-8340.
  • Jingwu Wang, Hongjie Zhang, Shaokui Cao, Jun Liu and Songjie Liu, 2001. Toughened Polypropylene with Balanced Rigidity V. Melt Rheological Properties, Polym. Adv. Technol., 12, 734-9.
  • Hongjie Zhang, Jingwu Wang, Shaokui Cao and Yong Wang, 2001. Toughened Polypropylene with Balanced Rigidity IV. Morphology, Crystallization Behavior and Thermal Properties, J. Appl. Polym. Sci., 79, 1351-1358.
  • Hongjie Zhang, Jingwu Wang, Jing Li, Shaokui Cao and Aiguo Shan, 2001. Toughened Polypropylene with Balanced Rigidity III. Compositions and Mechanical Properties, J. Appl. Polym. Sci., 79, 1345-1350.
  • Hongjie Zhang, Jingwu Wang, Manjiao Chen, Shaokui Cao and Xueqing Wang, 2000. Toughened Polypropylene with Balanced Rigidity II. Morphology, Melt Flow Rate and Melting Point of Toughening Master Batch, Polym. Adv. Technol., 11, 342-8.
  • Hongjie Zhang, Jingwu Wang, Shaokui Cao and Aiguo Shan, 2000. Toughened Polypropylene with Balanced Rigidity I. Preparation and Chemical Structure of Toughening Master Batch, Polym. Adv. Technol., 11, 334-41.
  • Zhang H.; Abraham N.; Khan L.; Gobel V. RNAi-based biosynthetic pathway screens to identify in vivo functions of non-nucleic acid–based metabolites such as lipids. Nature protocols 2015,10,,5, 681-700.

Book Chapters

  • Hongjie Zhang and Yoshihiro Ito, 2002. Smart Material Systems Using Signal-Responsive Polyelectrolytes, in “Handbook of Polyelectrolytes and Their Applications” edited by S. K. Tripathy, J. Kumar and H. S. Nalwa, American Scientific Publishers, 183-206.