Contact information
Address (Office) E12-4038 Wei GE
(Lab) N22-2037
Phone (Office / Lab) 8822 4996
Fax 8822 2314
Email weige@umac.mo
Education 
NSERC postdoctoral fellow National Institute for Basic Biology (NIBB), Okazaki, Japan (1993-1995)
Ph.D. University of Alberta, Edmonton, Canada (1988-1993)
M.Sc. Institute of Hydrobiology, Academia Sinica, Wuhan, China (1982-1985)
B.Sc. Department of Biology, Nanjing University, Nanjing, China (1978-1982)
Positions 
2013-present Associate Dean/ Chair Professor/ Head of Cancer Centre, Faculty of Health Sciences, University of Macau
2004-present Professor, School of Life Sciences, The Chinese University of Hong Kong
2006-present Adjunct Professor, College of Life Sciences, Sun Yat-sen University, Guangzhou, China
2009-present Adjunct Professor, School of Biomedical Sciences, The Chinese University of Hong Kong
1999-2004 Associate Professor, Department of Biology, The Chinese University of Hong Kong
1995-1999 Assistant Professor, Department of Biology, The Chinese University of Hong Kong
Research Interests
My research focuses on functional analysis of the brain-pituitary-ovary axis using zebrafish as the model.  Our current interests include: (1) endocrine regulation of reproduction by the reproductive and growth axes; (2) intra-follicular paracrine/autocrine communication network in the ovary; (3) impacts of environmental endocrine-disrupting chemicals (EDCs) on reproduction and public health; and (4) zebrafish as a model for aging, human diseases and drug discovery.  Our research involves using a variety of techniques in molecular and cell biology, physiology and genetics, including the newly-emerged genome-editing technologies, i.e., TALEN and CRISPR/Cas9.
Representative Publications
  1. Wang, C., Liu, D., Chen, W., Ge, W., Hong, W., Zhu, Y. and Chen, S. Progestin increases the expression of gonadotropins in the pituitaries of male zebrafish (Danio rerio). Journal of Endocrinology 2016 Jul; 230(1):143-56.
  2. Zhou R, Yu S M Y, Ge W. Expression and functional characterization of intrafollicular GH–IGF system in the zebrafish ovary. General and comparative endocrinology 2016 Jun 1;232:32-42.
  3. Huang, W., Wang, J., Liang, Y., Ge, W., Wang, G., Li, Y. and Chung, H.Y. Potent anti-angiogenic component in Croton crassifolius and its mechanism of action. Journal of Ethnopharmacology 2015 Dec 4;175:185-91.
  4. Yao K.; Ge W. Differential regulation of kit ligand A (kitlga) expression in the zebrafish ovarian follicle cells–Evidence for the existence of a cyclic adenosine 3′; 5′ monophosphate-mediated binary regulatory system during folliculogenesis. Molecular and cellular endocrinology 2015;402;21-31.
  5. Huang W.; Wang J.; Liang Y.; Ge W.; Wang G.; Li Y.; Chung HY. Potent anti-angiogenic component in Croton crassifolius and its mechanism of action. Journal of ethnopharmacology 2015; 175; 185-191.
  6. Zhang J.; Ge W.; Yuan Z. In vivo three-dimensional characterization of the adult zebrafish brain using a 1325 nm spectral-domain optical coherence tomography system with the 27 frame/s video rate. Biomedical optics express 2015; 6; 10; 3932-3940.
  7. Zhang Z.; Lau SW.; Zhang L.; Ge W. Disruption of Zebrafish Follicle-stimulating Hormone Receptor (fshr) but Not Luteinizing Hormone Receptor (lhcgr) Gene by TALEN Leads to Failed Follicle Activation in Females Followed by Sexual Reversal to Males. Endocrinology 2015 Oct;156(10):3747-62.
  8. Zhang Z.; Zhu B.; Ge W. Genetic Analysis of Zebrafish Gonadotropin (FSH and LH) Functions by TALEN-Mediated Gene Disruption. Molecular Endocrinology 2015;29;1;76-98.
  9. Zhang S.; Zhang Y.; Chen W.; Wu Y.; Ge W.; Zhang L.; Zhang W. Aromatase (Cyp19a1b) in the Pituitary Is Dynamically Involved in the Upregulation of lhb But Not fshb in the Vitellogenic Female Ricefield Eel Monopterus albus. Endocrinology 2015;155;11;4531-4541.
  10. Yao, K., Lau, S.-W. and Ge, W. Differential Regulation of Kit Ligand A Expression in the Ovary by IGF-I via Different Pathways.  Molecular Endocrinology 2014 Jan;28(1):138-50.
  11. Li, C.W. and Ge, W. Regulation of the activin-inhibin-follistatin system by bone morphogenetic proteins in the zebrafish ovary. Biology of Reproduction 2013 Sep 12;89(3):55.
  12. Chen, W. and Ge, W. 2013 Gonadal differentiation and puberty onset in the zebrafish – evidence for dependence of puberty onset on body growth but not age in females. Molecular Reproduction and Development 80:384-392
  13. Yao, K. and Ge, W. 2013 Spatial Distribution and Receptor Specificity of Zebrafish Kit System – Evidence for a Kit-mediated Bi-directional Communication System in the Preovulatory Ovarian Follicle. PLoS One 8:e56192
  14. Chung, C.-K. and Ge, W. 2012 Epidermal growth factor differentially regulates activin subunits in the zebrafish ovarian follicle cells via diverse signaling pathways. Molecular and Cellular Endocrinology 361:133-142
  15. Chen, W. and Ge, W. 2012 Ontogenic expression profiles of gonadotropins (fshb and lhb) and growth hormone (gh) during sexual differentiation and puberty onset in female zebrafish. Biology of Reproduction 86:1-11
  16. Liu, K.-C., Lin, S.-W. and Ge, W. 2011 Differential regulation of gonadotropin receptors (fshr and lhcgr) by estradiol in the zebrafish ovary involves nuclear estrogen receptors that are likely located on the plasma membrane. Endocrinology 152:4418-4430
  17. Zhou, R., Tsang, A.H.K., Lau, S.-W. and Ge, W. 2011 Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors in the zebrafish ovary – evidence for potential dual roles of pacap in controlling final oocyte maturation. Biology of Reproduction 85:615-625 (cover story)
  18. Li, C.W. and Ge, W. 2011 Spatiotemporal expression of bone morphogenetic protein family ligands and receptors in the zebrafish ovary – a potential paracrine signaling mechanism for oocyte-follicle cell communication. Biology of Reproduction 85:977-986
  19. Yao, K. and Ge, W. 2010 Kit system in the zebrafish ovary – Evidence for functional divergence of two isoforms of kit (kita and kitb) and kit ligands (kitlga and kitlgb) during folliculogenesis. Biology of Reproduction 82:1216-1226
  20. Liu, L. and Ge, W. 2007 Growth differentiation factor 9 and its spatiotemporal expression and regulation in the zebrafish ovary. Biology of Reproduction 76:294-302
  21. Ge, W. 2005 Intrafollicular paracrine communication in the zebrafish ovary: The state of the art of an emerging model for the study of vertebrate folliculogenesis. Molecular and Cellular Endocrinology 237:1-10 (Invited At-the-Cutting-Edge review)
  22. Kwok, H.-F., So, W.-K., Wang, Y. and Ge, W. 2005 Zebrafish gonadotropins and their receptors: I. Cloning and characterization of zebrafish follicle-stimulating hormone and luteinizing hormone receptors (Fshr and Lhr) – Evidence for their distinct functions in follicle development. Biology of Reproduction 72:1370-81
  23. So, W.-K., Kwok, H.-F. and Ge, W. 2005 Zebrafish gonadotropins and their receptors: II. Cloning and characterization of zebrafish follicle-stimulating hormone (FSH) and luteinizing hormone (LH) subunits – Their spatial-temporal expression patterns and receptor specificity. Biology of Reproduction 72:1382-96
  24. Wang, Y. and Ge, W. 2004 Developmental profiles of activin βA, βB and follistatin expression in the zebrafish ovary – evidence for their differential roles during sexual maturation and ovulatory cycle. Biology of Reproduction 71:2056-2064
  25. Wang, Y. and Ge, W. 2004 Cloning of epidermal growth factor (EGF) and EGF receptor (EGFR) from the zebrafish ovary and its potential roles in the regulation of ovarian activin/follistatin system. Biology of Reproduction 71:749-760
  26. Wang, Y., Wong, A.O.L. and Ge, W. 2003 Cloning, regulation of mRNA expression and function of a new isoform of pituitary adenylate cyclase-activating polypeptide (PACAP) in the zebrafish ovary. Endocrinology 144:4799-4810
  27. Wang, Y. and Ge, W. 2003 Spatial expression patterns of activin and its signaling system in the zebrafish ovarian follicle – evidence for paracrine action of activin on the oocytes. Biology of Reproduction 69:1998-2006
  28. Wang, Y. and Ge, W. 2003 Involvement of cyclic adenosine 3’,5’-monophosphate in the differential regulation of activin bA and bB expression by gonadotropin in the zebrafish ovarian follicle cells. Endocrinology 144:491-499
  29. Pang, Y. and Ge, W. 2002 Epidermal growth factor (EGF) and transforming growth factor-a (TGF-a) promote zebrafish oocyte maturation in vitro: potential role of the ovarian activin regulatory system. Endocrinology 143:47-54
Research Grants
  1. 2009-2013 (Co-PI) Action mechanisms of endocrine disrupting chemicals in fish reproductive axis [Hong Kong Area of Excellence (AoE) Grant on Marine Environmental Research and Innovative Technology, HKD1,000,000]
  2. 2009-2013 (PI) A zebrafish story on inhibin, an important reproductive hormone that has been largely ignored in lower vertebrates – Does it serve as an ovarian signal to trigger the brain-pituitary axis for oocyte maturation and ovulation? [Hong Kong Research Grants Council (RGC) Grant, HKD1,246,502]
  3. 2008-2011 (PI) Proteomic Analysis of Zebrafish Folliculogenesis Identifies Y-Box Binding Protein 1 (YB-1) in the Primary Growth Follicles – Does YB-1 Play a Gate-keeping Role in Ovarian Follicle Recruitment? (Hong Kong RGC Grant, HKD1,292,447)
  4. 2008-2015 (PI) Functional analysis of the brain-pituitary-ovarian axis in the zebrafish and its applications (CUHK Focused Investment Scheme, HKD1,000,000)
  5. 2008-2013 (Co-PI) Centre for Cell and Developmental Biology (CUHK Focused Investment Scheme, HKD8,800,000)
  6. 2007-2009 (PI) Functional analysis of pituitary-ovarian axis in the zebrafish – Role of EGFR in LHR signaling in the ovary, a continual story of the intraovarian EGF/EGFR network (Hong Kong RGC Grant, HKD689,996)
  7. 2006-2009 (PI) Functional analysis of pituitary-gonadal axis in the zebrafish – Role of growth hormone (GH) in the ovary as both endocrine hormone and paracrine growth factor (Hong Kong RGC Grant, HKD1,203,784)
  8. 2005-2008 (PI) Functional analysis of pituitary-gonadal axis in the zebrafish – Why do fish need two gonadotropins, and what is the physiological relevance of FSH? (Hong Kong RGC Grant, HKD1,397,914)
  9. 2004-2007 (PI) Intrafollicular Communication in the Zebrafish Ovary – Roles of GDF-9 from the oocyte in orchestrating follicle development (Hong Kong RGC Grant, HKD1,321,920)
  10. 2002-2004 (PI) Epidermal growth factor (EGF) in the ovary of zebrafish – How is it related to the ovarian activin system in controlling oocyte development? (Hong Kong RGC Grant, HKD896,000)
  11. 2001-2003 (PI) Activin System in the Pituitary: How Important Is It in the Differential Expression of Fish FSH and LH? (Hong Kong RGC Grant, HKD699,600)
  12. 1999-2001 (PI) Transcriptional Regulation of Gonadotropin-I and II (GTH-I and II) Genes in the Goldfish by Activin – Functional Analysis of Cis-acting Elements that Mediate Activin Stimulation of GTH-I and Inhibition of GTH-II Expression in the Goldfish, Carassius auratus (Hong Kong RGC Grant, HKD789,000)
  13. 1996-1998 (PI) Activin Regulation of Pituitary Gonadotropin Gene Expression and Oocyte Development in Goldfish, Carassius auratus (Hong Kong RGC Grant, HKD865,000)
Awards
2007 The VC’s Exemplary Teaching Award,
The Chinese University of Hong Kong
2003 The VC’s Exemplary Teaching Award,
The Chinese University of Hong Kong
2011 Exemplary Teaching Award
Faculty of Science, The Chinese University of Hong Kong
2007 Exemplary Teaching Award
Faculty of Science, The Chinese University of Hong Kong
2003 Exemplary Teaching Award
Faculty of Science, The Chinese University of Hong Kong
2001 Exemplary Teaching Award
Faculty of Science, The Chinese University of Hong Kong
Professional Activities
Professional membership

  1. The Endocrine Society
  2. Society for the Study of Reproduction (SSR)
  3. American Association for the Advancement of Science (AAAS)
  4. The Asia and Oceania Society for the Comparative Endocrinology (AOSCE)
  5. Hong Kong Society of Developmental Biology
  6. Council member, the International Federation of Comparative Endocrinological Societies (IFCES) (2009-2013)
  7. Council member, the Asia and Oceania Society for Comparative Endocrinology (AOSEC) (2012-present)
  8. Council member, the Chinese Society of Comparative Endocrinology (中國比較內分泌學會理事) (2013-)
  9. International Preparatory Committee on the Formation of the Society of Fish Endocrinology (2012-)

 
Editorial service for academic journals

  1. Associate editor, Frontiers in Endocrinology (Experimental Endocrinology)
  2. Editorial board, General and Comparative Endocrinology (GCE)
  3. Editorial board, Asian Pacific Journal of Reproduction
  4. Regional editor, Theriogenology Insight
  5. Guest editor, International Journal of Endocrinology (Special issue on Recent Advances in Molecular Comparative Reproductive Endocrinology)

Reviewer of grant applications

  1. Research Grants Council (RGC), Hong Kong (1997, 2007, 2008)
  2. The National Science Foundation (NSF), USA (2004)
  3. The South Plins Foundation, Lubbock, Texas, USA (2003)
  4. Israel Science Foundation (2008)
  5. The Natural Sciences and Engineering Research Council of Canada (NSERC, Canada)  (2009)
  6. Royal Society Newton International Fellowships, UK (2008)
  7. National Natural Science Foundation of China (NSFC) 國家自然科學基金委員會重點項目 (2012, 2013)
  8. Technology and Business Development Fund (CUHK, 2013)
Others
Conference Presentations

  1. Ge, W. Abstract of the 27th Conference of European Comparative Endocrinologists (CECE2014), “Kit System and Its Role in the Paracrine Regulation of Follicle Development in the Zebrafish.”2015
  2. Ge, W. Abstract of the Gordon Research Conference on IGF & Insulin System in Physiology & Disease, “IGF Regulation of Y-Box Binding Protein 1 (YB-1; Ybx1) in the Ovary: A Potential Mechanism of How the Growth Axis Influences Ovarian Follicle Activation”2015