Contact Information
Address (Office) E12-3007 Kathy LUO
(Lab) N22-4037
Phone (Office) 8822 4233
(Lab) 8822 4267
Fax 8822 2314
Email Kluo@umac.mo
Education
Postdoctoral Fellow Division of Biology, California Institute of Technology, Pasadena, California, USA (1995-1998)
Ph.D. Department of Microbiology and Immunology, The University of British Columbia, Vancouver, Canada (1990-1995)
M.S. Peking University, Department of Biology, Beijing, China (1982-1985)
B.S. Peking University, Department of Biology, Beijing, China (1978-1982)
Positions
2016.01 -present Professor, Faculty of Health Sciences, University of Macau
2009.052015.12 Associate Professor, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore
2003.12-2009.05 Visiting Assistant Professor, Bioengineering Graduate Program, Department of Chemical and Biomolecular Engineering, The Hong Kong University of Science and Technology, Hong Kong
1998.082003.12 Research Associate, Department of Biology, The Hong Kong University of Science and Technology, Hong Kong
1989.091990.08 Research Assistant, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
1987.09-1989.08 Research Assistant, Department of Medicine, University of Colorado, Denver, Colorado, USA
Research Interests
  • Cancer biology: Identify driver proteins that can increase cancer cells’ survival in circulation, metastasis and during chemotherapy.
  • Anti-cancer drug discovery: Discover new agents against metastatic and drug resistant cancer cells.
  • Metabolic diseases: Study diabetes-related endothelial cell dysfunction and discover new biomarkers for diagnosis and treatment of diabetes.
  • Aging research and bio-detections: Generate transgenic zebrafish for aging and toxicity study.
Representative Publications
(Citations: 2,200, h-index: 26, Web of Science, *: corresponding & co-corresponding authors)

  1. Dalan R, Liu X, Goh LL, Bing S, Luo KQ* (2017) Endothelial cell apoptosis correlates with low haptoglobin concentrations in diabetes. Diabetes and Vascular Disease Research, in press.
  2. Chiew GGY, Wei N, Sultania S, Lim S, Luo KQ* (2017) Bioengineered three-dimensional co-culture of cancer cells and endothelial cells: a model system for dual analysis of tumor growth and angiogenesis. Biotechnology and Bioengineering, published on May 8, 2017, DOI: 10.1002/bit.26297.
    http://onlinelibrary.wiley.com/doi/10.1002/bit.26297/full
  3. Regmi S, Fu A, Luo KQ* (2017) High shear stresses under exercise condition destroy circulating tumor cells in a microfluidic system. Scientific Reports, 7:39975. DOI: 10.1038/srep39975.
    http://www.nature.com/articles/srep39975
  4. Wang Q, Wei N, Liu X, Luo KQ* (2017) Enhancement of the bioavailability of a novel anticancer compound (acetyltanshinone IIA) by encapsulation within mPEG-PLGA nanoparticles: a study of formulation optimization, toxicity, and pharmacokinetics. Oncotarget, 8:12013-12030. DOI: 10.18632/oncotarget.14481.
    http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=14481&author-preview=b69
  5. Ma S, Fu A, Chiew GGY, Luo KQ* (2016) Hemodynamic shear stress stimulates migration and extravasation of tumor cells by elevating cellular oxidative level. Cancer Letters, 388: 239-248. DOI: 10.1016/j.canlet.2016.12.001.
    http://www.sciencedirect.com/science/article/pii/S0304383516307467
  6. Qiu Y, Taichi M, Wei N, Yang H, Luo KQ, Tam J (2016) An orally active bradykinin B1 receptor antagonist engineered as a bifunctional chimera of sunflower trypsin inhibitor. Journal of Medicinal Chemistry, 2017, 60(1), pp 504-510. DOI: 10.1021/acs.jmedchem.6b01011.
    http://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.6b01011
  7. Fu A, Ma SJ, Wei N, Tan BXX, Tan EY, Luo KQ* (2016) High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin. Oncotarget, 7(31):50239-50257. DOI: 10.18632/oncotarget.10360.
    http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=10360.
  8. Zhu H, Fang Y, Zhen X, Wei N, Gao Y, Luo KQ, Xu CJ, Duan H, Ding D, Chen P, Pu K (2016) Multilayered semiconducting polymer nanoparticles with enhanced NIR fluorescence for molecular imaging in cells, zebrafish and mice. Chemical Science, DOI: 10.1039/C6SC01251E.
    http://pubs.rsc.org/en/content/articlepdf/2016/sc/c6sc01251e.
  9. Sin SH, Xu J, Fung KY, Ng, KM, Luo KQ (2016) Evaluation of bacterial consortium construction approaches for anaerobic decolorization. Journal of Environmental Chemical Engineering, 4:1191-1198.
    http://www.sciencedirect.com/science/article/pii/S221334371630029X.
  10. Bhave MS, Ammar, Anand HP, Luo KQ, Teoh SH (2015) Effect of heat-inactivated clostridium sporogenes and its conditioned media on 3-dimensional colorectal cancer cell models. Scientific Reports, 5:15681, DOI: 10.1038/srep15681.
    nature.com/articles/srep15681.
  11. Anand P, Fu A, Teoh SH, Luo KQ* (2015) Application of a fluorescence resonance energy transfer (FRET)-based biosensor for detection of drug-induced apoptosis in a 3D breast tumor model. Biotechnology and Bioengineering, 112:1673-1682.
    http://www.ncbi.nlm.nih.gov/pubmed/25728592.
  12. Geraldine Giap Ying Chiew, Afu Fu, Luo KQ* (2015) Physical supports from liver cancer cells are essential for differentiation and remodeling of endothelial cells in a HepG2-HUVEC co-culture model. Scientific Reports, 5:10801.
    http://www.ncbi.nlm.nih.gov/pubmed/26053957.
  13. Zheng XT, Ananthanarayanan A, Luo KQ, Chen P (2015) Glowing graphene quantum dots and carbon dots: properties, syntheses, and biological applications. Small, 11(14):1620-1636.
    http://www.ncbi.nlm.nih.gov/pubmed/25521301.
  14. Kannadorai RK, Chiew GGY, Luo KQ, Liu Q. (2015) Dual functions of gold nanorods as photothermal agent and autofluorescence enhancer to track cell death during plasmonic photothermal therapy, Cancer Letters, 357(1):152-159.
    http://www.sciencedirect.com/science/article/pii/S0304383514006788.
  15. Gao Y, Wang Y, Fu A, Shi W, Yeo D, Kolachina M, Luo KQ, Ow H, Xu CJ (2015) Tracking mesenchymal stem cell tumor-homing using fluorescent silica nanoparticles. Journal of Materials Chemistry B, Issue 3:1245-1253.
    http://pubs.rsc.org/en/Content/ArticleLanding/2015/TB/c4tb01452a#!divAbstract.
  16. Feng C, Huang SX, Gao XM, Xu HX*, Luo KQ* (2014) Characterization of proapoptotic compounds from the bark of Garcinia oblongifolia. Journal of Natural Products, 77(5):1111-1116.
    http://www.ncbi.nlm.nih.gov/pubmed/24754786.
  17. Yu T, Zhou Z, Mu Y, Lopes G, Luo KQ* (2014) A novel anti-cancer agent, acetyltanshinone IIA, inhibits oestrogen receptor positive breast cancer cell growth by down-regulating the oestrogen receptor. Cancer Letters, 346(1):94-103.
    http://www.ncbi.nlm.nih.gov/pubmed/24374015.
  18. Xu JJ and Luo KQ* (2014) Enhancing the solubility and bioavailability of isoflavone by particle size reduction using a supercritical carbon dioxide-based precipitation process. Chemical Engineering Research and Design, 92:2542-2549.
    http://www.sciencedirect.com/science/article/pii/S026387621400149X.
  19. Liu XF, Yu JQ, Dalan R, Liu AQ, Luo KQ* (2014) Biological factors in plasma from diabetes mellitus patients enhance hyperglycaemia and pulsatile shear stress-induced endothelial cell apoptosis. Integrative Biology, 6(5):511-522. Selected as the cover image of the journal.
    http://www.ncbi.nlm.nih.gov/pubmed/24643402.
  20. Yu Y, Li Jie, Chen S, Hong Y, Ng KM, Luo KQ*, Tang BZ* (2013) Thiol reactive molecule with dual-emission-enhancement property for specific prestaining of cysteine containing proteins in SDS-PAGE. ACS Applied Materials & Interfaces, 5(11):4613-4616.
    http://pubs.acs.org/doi/abs/10.1021/am401486h.
  21. Gao XM*, Cui, MZ, Yu T, Hu QF, Pu JX, Du X, Liu TC, Luo KQ* (2013) A novel xanthone from Garcinia oligantha. Helvetica Chimica Acta, 96(3):494-498.
    http://onlinelibrary.wiley.com/doi/10.1002/hlca.201200245/abstract.
  22. Lin CS, Xu JJ, Ng KM, Wibowo C, Luo KQ (2013) Encapsulation of a low aqueous solubility substance in a biodegradable polymer using supercritical fluid extraction of emulsion. Industrial & Engineering Chemistry Research, 52(1):134-141.
    http://pubs.acs.org/doi/abs/10.1021/ie300612r.
  23. Yu T, Li Y, Yang T, Gong Y, Sudibya HG, Chen P, Luo KQ, Liao K (2013) Fabrication of all-in-one multifunctional phage liquid crystalline fibers, RSC Advances, 3(43):20437-20445.
    http://pubs.rsc.org/en/Content/ArticleLanding/2013/RA/c3ra43034k#!divAbstract.
  24. Yu JQ, Liu XF, Chin LK, Liu AQ, Luo KQ* (2013) Study of endothelial cell apoptosis using fluorescence resonance energy transfer (FRET) biosensor cell line with hemodynamic microfluidic chip system. Lab on a Chip, 13(14):2693-2700.
    http://www.ncbi.nlm.nih.gov/pubmed/23620256.
  25. Feng C, Zhou LY, Yu T, Xu G, Tian HL, Xu JJ, Xu HX*, Luo KQ* (2012) A new anticancer compound, Oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through Bax activation. International Journal of Cancer, 131(6):1445-1454.
    http://www.ncbi.nlm.nih.gov/pubmed/22116711.
  26. Wu ZM, Ling L, Zhou LY, Guo XD, Jiang W, Qian Y, Luo KQ, Zhang LJ (2012) Novel preparation of PLGA/HP55 nanoparticles for oral insulin delivery, Nanoscale Research Letters, Volume: 7, Article: 299.
    http://www.ncbi.nlm.nih.gov/pubmed/22682064.
  27. Wu ZM, Zhou LY, Guo XD, Jiang W, Ling L, Qian Y, Luo KQ, Zhang LJ (2012) HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin. International Journal of Pharmaceutics, 425(1-2):1-8.
    http://www.ncbi.nlm.nih.gov/pubmed/22248666.
  28. Gao XM, Yu T, Pu Cui MZ, Pu JX, Du X, Han QB, Hu QF, Liu TC, Luo KQ*, Xu HX* (2012) Identification and evaluation of apoptotic compounds from Garcinia oligantha. Bioorganic & Medicinal Chemistry Letters, 22(6):2350-2353.
    http://www.ncbi.nlm.nih.gov/pubmed/22365754.
  29. Zhu XM, Fu AF, Luo KQ* (2012) A high-throughput fluorescence resonance energy transfer (FRET)-based endothelial cell apoptosis assay and its application for screening vascular disrupting agents. Biochemical and Biophysical Research Communications, 418(4):641-646.
    http://www.ncbi.nlm.nih.gov/pubmed/22290227.
  30. Yu Y, Qin A, Feng C, Lu P, Ng KM, Luo KQ*, Tang BZ* (2012) An amine-reactive tetraphenylethylene derivative for protein detection in SDS-PAGE. Analyst, 137(23): 5592-5596, DOI: 10.1039/c2an36002k.
  31. Yu Y, Liu J, Zhao Z, Ng KM, Luo KQ*, Tang BZ* (2012) Facile preparation of non-self-quenching fluorescent DNA strands with the degree of labeling up to the theoretic limit. Chemical Communications, 48(51):6360-6362.
    http://www.ncbi.nlm.nih.gov/pubmed/22618018.
  32. Yu Y, Feng C, Hong Y, Liu J, Chen S, Ng KM, Luo KQ*, Tang BZ* (2011). Cytophilic fluorescent bioprobes for long-term cell tracking. Advanced Materials, 23(29):3298-3302.
    http://www.ncbi.nlm.nih.gov/pubmed/21671445.
  33. Chin LK, Yu JQ, Fu Y, Yu T, Liu AQ, Luo KQ* (2011) Production of reactive oxygen species in endothelial cells under different pulsatile shear stresses and glucose concentrations. Lab on a Chip, 11(11):1856-1863.
    http://www.ncbi.nlm.nih.gov/pubmed/21373653.
  34. Lam KW, Xu JJ, Ng KM, Wibowo C, Lin G, Luo KQ (2010) Pharmaceutical salt formation guided by phase diagrams. Industrial & Engineering Chemistry Research, 49:12503-12512.
    http://pubs.acs.org/doi/abs/10.1021/ie902080k.
  35. Tian HL, Yu T, Xu NN, Feng C, Zhou LY, Luo HW, Chang DC, Le XF, Luo KQ* (2010) A novel compound modified from tanshinone inhibits tumor growth in vivo via activation of the intrinsic apoptotic pathway. Cancer Letters, 297(1):18-30.
    http://www.ncbi.nlm.nih.gov/pubmed/20494511.
  36. Han QB, Yu T, Lai F, Zhou Y, Feng C, Wang WN, Fu XH, Lau CB, Luo KQ, Xu HX, Sun HD, Fung KP, Leung PC (2010) Quick identification of apoptosis inducer from Isodon eriocalyx by a drug discovery platform composed of analytical high-speed counter-current chromatography and the fluorescence-based caspase-3 biosensor detection. Talanta, 82(4):1521-1527.
    http://www.ncbi.nlm.nih.gov/pubmed/20801367.
  37. Hong Y, Feng C, Yu Y, Liu J, Lam JW, Luo KQ, Tang BZ (2010) Quantitation, visualization, and monitoring of conformational transitions of human serum albumin by a tetraphenylethylene derivative with aggregation-induced emission characteristics. Analytical Chemistry, 82(16):7035-7043.
    http://pubs.acs.org/doi/abs/10.1021/ac1018028.
  38. Liu X, Yu T, Gao XM, Zhou Y, Qiao CF, Peng Y, Chen SL, Luo KQ*, Xu HX* (2010) Apoptotic effects of polyprenylated benzoylphloroglucinol derivatives from the twigs of Garcinia multiflora. Journal of Natural Products, 73(8):1355-1359.
    http://www.ncbi.nlm.nih.gov/pubmed/20681570.
  39. Gao XM, Yu T, Lai FS, Zhou Y, Liu X, Qiao CF, Song JZ, Chen SL, Luo KQ*, Xu HX* (2010) Identification and evaluation of apoptotic compounds from Garcinia paucinervis. Bioorganic & Medicinal Chemistry, 18(14):4957-4964.
    http://www.ncbi.nlm.nih.gov/pubmed/20594858.
  40. Dai W, Zheng YZ, Luo KQ, Wu H (2010) A prototypic microfluidic platform generating stepwise concentration gradients for real-time study of cell apoptosis. Biomicrofluidics, Vol:4, Issue:2, Article number:024101.
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917874/.
  41. Gao XM, Yu T, Lai FS, Pu JX, Qiao CF, Zhou Y, Liu X, Song JZ, Luo KQ*, Xu HX* (2010) Novel polyisoprenylated benzophenone derivatives from Garcinia paucinervis. Tetrahedron Letters, 51(18):2442-2446.
    http://www.sciencedirect.com/science/article/pii/S0040403910003722.
  42. Han QB, Zhou Y, Feng C, Xu G, Huang SX, Li SL, Qiao CF, Song JZ, Chang DC, Luo KQ*, Xu HX* (2009) Bioassay guided discovery of apoptosis inducers from gamboge by high-speed counter-current chromatography and high-pressure liquid chromatography/ electrospray ionization quadrupole time-of-flight mass spectrometry. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 877(4):401-407.
    http://www.ncbi.nlm.nih.gov/pubmed/19124287.
  43. Huang SX, Feng C, Zhou Y, Xu G, Han QB, Qian CF, Chang DC, Luo KQ*, Xu HX* (2009) Bioassay-guided isolation of xanthones and polycyclic prenylated acylphloro glucinols from Garcinia oblongifolia. Journal of Natural Products, 72(1):130-135.
    http://www.ncbi.nlm.nih.gov/pubmed/19113969.
  44. Yu Y, Hong YN, Feng C, Liu J, Lam JWY, Faisal M, Ng KM, Luo KQ*, Tang BZ* (2009) Synthesis of an AIE-active fluorogen and its application in cell imaging. Science in China Series B: Chemistry, 52(1):15-19.
    http://link.springer.com/article/10.1007%2Fs11426-009-0008-0.
  45. Xu G, Feng C, ZhouY, Han QB, Qian CF, Huang SX, Chang DC, Zhao QS, Luo KQ*, Xu HX* (2008) Bioassay and ultraperformance liquid chromatograph/mass spectrometry guided isolation of apoptosis-inducing benzophenones and xanthones from the pericarp of Garcinia yunnanensis Hu. Journal of Agricultural and Food Chemistry, 56(23):11144-11150.
    http://www.ncbi.nlm.nih.gov/pubmed/19007298.
  46. Zhou L, Chan WK, Xu N, Xiao K, Luo H, Luo KQ, Chang DC (2008) Tanshinone IIA, an isolated compound from Salvia miltiorrhiza Bunge, induces apoptosis in HeLa cells through mitotic arrest. Life Sciences, 83(11-12):394-403.
    http://www.ncbi.nlm.nih.gov/pubmed/18721815.
  47. Han QB, Yang NY, Tian HL, Qiao CF, Song JZ, Chang DC, Chen SL, Luo KQ*, Xu HX* (2008) Xanthones with growth inhibition against HeLa cells from Garcinia xipshuanbannaensis. Phytochemistry, 69(11):2187-2192.
    http://www.ncbi.nlm.nih.gov/pubmed/18614188.
  48. Zhang EJ, Ng KM, Luo KQ* (2008) Response to comment on extraction and purification of isoflavones from soybeans and characterization of their estrogenic activities. Journal of Agricultural and Food Chemistry, 56(9):3428-3430.
    http://pubs.acs.org/doi/abs/10.1021/jf703630r.
  49. Wei B, Cheng I, Luo KQ, Mi YL (2008) Capture and release of protein by a reversible DNA-induced sol-gel transition system. Angewandte Chemie-International Edition, 47(2):331-333.
    http://www.ncbi.nlm.nih.gov/pubmed/18033711.
  50. Han QB, Tian HL, Yang NY, Qiao CF, Song JZ, Chang DC, Luo KQ*, Xu HX* (2008) Polyprenylated xanthones from Garcinia lancilimba showing apoptotic effects against HeLa-C3 cells. Chemistry & Biodiversity, 5(12):2710-2717.
    http://www.ncbi.nlm.nih.gov/pubmed/19089829.
  51. Zhang EJ, Ng KM, Luo KQ* (2007) Extraction and purification of isoflavones from soybeans and characterization of their estrogenic activities. Journal of Agricultural and Food Chemistry, 55(17):6940-6950.
    http://www.ncbi.nlm.nih.gov/pubmed/17658826.
  52. Tian H, Ip L, Luo H, Chang DC, Luo KQ* (2007) A high throughput drug screen based on fluorescence resonance energy transfer (FRET) for anticancer activity of compounds from herbal medicine. British Journal of Pharmacology, 150(3):321-334.
    http://www.ncbi.nlm.nih.gov/pubmed/17179946.
  53. Harjo B, Wibowo C, Zhang EJ, Luo KQ, Ng KM (2007) Development of process alternatives for separation and purification of isoflavones. Industrial & Engineering Chemistry Research, 46(1):181-189.
    http://pubs.acs.org/doi/abs/10.1021/ie061027f.
  54. Zhou LL, Zhou LY, Luo KQ, Chang DC (2005) Smac/DIABLO and cytochrome c are released from mitochondria through a similar mechanism during UV-induced apoptosis. Apoptosis, 10(2):289-299.
    http://www.ncbi.nlm.nih.gov/pubmed/15843890.
  55. Luo KQ*, Chang DC (2004) The gene-silencing efficiency of siRNA is strongly dependent on the local structure of mRNA at the targeted region. Biochemical and Biophysical Research Communications, 318(1):303-310.
    http://www.ncbi.nlm.nih.gov/pubmed/15110788.
  56. Chang DC, Xu NH, Luo KQ (2003) Degradation of cyclin B is required for the onset of anaphase in mammalian cells. Journal of Biological Chemistry, 278(39):37865-37873.
    http://www.ncbi.nlm.nih.gov/pubmed/12865421.
  57. Luo KQ*, Elsasser S, Chang DC, Campbell JL (2003) Regulation of the localization and stability of Cdc6 in living yeast cells. Biochemical and Biophysical Research Communications, 306(4):851-859.
    http://www.ncbi.nlm.nih.gov/pubmed/12821120.
  58. Xu NH, Luo KQ, Chang DC (2003) Ca2+ signal blockers can inhibit M/A transition in mammalian cells by interfering with the spindle checkpoint. Biochemical and Biophysical Research Communications, 306(3):737-745.
    http://www.ncbi.nlm.nih.gov/pubmed/12810081.
  59. Luo KQ*, Yu VC, Pu YM, Chang DC (2003) Measuring dynamics of caspase-8 activation in a single living HeLa cell during TNF alpha-induced apoptosis. Biochemical and Biophysical Research Communications, 304(2):217-222.
    http://www.ncbi.nlm.nih.gov/pubmed/12711301.
  60. Pu YM, Luo KQ, Chang DC (2002) A Ca2+ signal is found upstream of cytochrome c release during apoptosis in HeLa cells. Biochemical and Biophysical Research Communications, 299(5):762-769.
    http://www.ncbi.nlm.nih.gov/pubmed/12470644.
  61. Gao WH, Pu YM, Luo KQ, Chang DC (2001) Temporal relationship between cytochrome c release and mitochondrial swelling during UV-induced apoptosis in living HeLa cells. Journal of Cell Science, 114(15):2855-2862.
    http://www.ncbi.nlm.nih.gov/pubmed/11683418.
  62. Luo KQ*, Yu VC, Pu YM, Chang DC (2001) Application of the fluorescence resonance energy transfer method for studying the dynamics of caspase-3 activation during UV-induced apoptosis in living HeLa cells. Biochemical and Biophysical Research Communications, 283(5):1054-1060.
    http://www.ncbi.nlm.nih.gov/pubmed/11355879.
  63. Luo Q*, Michaelis C, Weeks G (1995) Cyclin B and Cdc2 expression and Cdc2 kinase activity during Dictyostelium DNA and Cell Biology, 14(11):901-908.
    http://www.ncbi.nlm.nih.gov/pubmed/7576176.
  64. Michaelis C, Luo Q, Weeks G (1995) A Dictyostelium-discoideum gene, which is highly related to mo15 from Xenopus, is expressed during growth but not during development. Biochemistry and Cell Biology, 73(1-2):51-58.
    http://www.ncbi.nlm.nih.gov/pubmed/7662315.
  65. Luo Q*, Michaelis C, Weeks G (1994) Overexpression of a truncated cyclin B gene arrests Dictyostelium cell-division during mitosis. Journal of Cell Science, 107:3105-3114.
    http://www.ncbi.nlm.nih.gov/pubmed/7699009.
  66. Schlech WF, Luo Q, Faulkner G, Galsworthy S (1994) Interaction of Listeria species with human cell monolayers. Clinical and Investigative Medicine, 17(1):9-17.
    http://www.ncbi.nlm.nih.gov/pubmed/8174317.
  67. Bessesen MT, Luo Q, Rotbart HA, Blaser MJ, Ellison RT (1990) Detection of Listeria-monocytogenes by using the polymerase chain reaction. Applied and Environmental Microbiology, 56(9):2930-2932.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC184869/.
  68. Ellison RT, Luo Q, Reller LB (1990) Enhancement of the activity of cefotaxime by iron-binding proteins. Journal of Antimicrobial Chemotherapy, 25(3):479-481.
Research Grants

Funding Obtained as a Principal Investigator (PI) at University of Macau (MOP3,415,300)

  1. PI, MOP1,500,000, MYRG (2017-00019-FHS). Using 3D Co/tri-culture Systems to Study Liver Cancer/stromal Interactions and Discover New Anticancer Agents. Application reference number. 01/01/2018 to 31/12/2020.
  2. PI, MOP1,665,300, FDCT (083/2016/A2). Exploring the Therapeutic Potentials of Targeting Antioxidant Proteins for Treating Metastatic and Doxorubicin Resistant Breast Cancer Cells. 27/03/2017 to 26/03/2020.
  3. PI, MOP250,000, University of Macau, Start-Up Research Grant (SRG2016-00068-FHS). Generating Transgenic Zebrafish Sensors for Detecting Toxic Agents. 01/05/2016 to 30/04/2019.

Funding Obtained as a Principal Investigator (PI) at NTU of Singapore (S$2,466,542 = US$1,926,986)

  1. PI, S$683,842, Ministry of Education, Singapore, Academic Research Fund Tier 2 (MOE2014-T2-1-025). Common mechanisms promoting circulating tumour cell survival and chemoresistance. 01/02/2015 to 31/12/2015.
  2. PI, S$657,700, National Research Foundation Competitive Research Programme (NRF-CRP8-2011-05). Pharmacological fingerprinting of selected herbal products. 01/09/2012 to 31/12/2015.
  3. PI, S$200,000, Ministry of Education, Singapore, Academic Research Fund Tier 1 (2014-T1-001-053). Investigating the roles of stromal and endothelial cells on tumorigenesis of hepatocellular carcinoma in 3D co/tri-culture systems. 01/11/2014 to 31/12/2015.
  4. PI, S$192,000, Johns Hopkins Singapore Research Fund, RCA-13-243-JHS. Generating an intravenous dosage form of a new anti-breast cancer agent and determining its pharmacokinetic profile and in vivo toxicity. 01/07/2014 to 31/12/2015.
  5. PI, S$151,000, National Research Foundation-Environment and Water Industry Development Council-Incentive for Research and Innovation Scheme (NRF-EWI-IRIS) (1102-IRIS-05-02). Optofluidic system for bacterial detection and identification. 01/12/2012 to 30/11/2015.
  6. PI, S$200,000, Ministry of Education, Singapore, Academic Research Fund Tier 1 (RG45/09). Discovering new anticancer drug candidates from Chinese medicinal herbs by a novel FRET-based high-throughput apoptosis assay. 01/02/2010 to 28/02/2014.
  7. PI, S$64,000, Nanyang Technological University-National Health Group (NTU-NHG) Innovation Collaboration Grant (ICG/13008). A pilot study evaluating caspase-3 activation as a novel marker of systemic toxicity in breast cancer patients receiving chemotherapy. 01/04/2013 to 30/09/2015.
  8. PI, S$48,000, Nanyang Technological University-National Health Group (NTU-NHG) Innovation Seed Grant (ISG/11023). Evaluating the growth inhibition effect of a new anticancer agent in animal with xenografted tumor derived from breast cancer patients. 01/12/2011 to 31/12/2013.
  9. PI, S$70,000, Seed Funding from Nanyang Institute of Technology in Health and Medicine (RG47/07). Pharmacokinetic and toxicity studies of a new anti-breast cancer agent (ATA) in animal models. 01/05/2011 to 30/04/2012.
  10. PI, S$200,000, Start-up grant from SCBE of NTU. 04/05/2009 to 30/09/2012.

Funding obtained as a Principal Investigator (PI) at HKUST of Hong Kong (HK$4,526,000 = US$580,256)

  1. PI, HK$3,800,000, Innovation and Technology, Commission of Hong Kong (ITF/006/08NP). Developing and manufacturing nano-structured oral dosage forms of isoflavone and insulin with improved bioavailability. 07/04/2009 to 06/06/2011.
  2. PI, HK$450,000, Research Project Competition of Hong Kong University of Science and Technology (RPC-07/08.EG19). Bioassay-guided systematic fractionation of TCM for rapid discovery of new anticancer compounds. 02/06/2008 to 31/05/2009.
  3. PI, HK$77,000, Research Grants Council of Hong Kong-Direct Allocation Grants (DAG04/05.EG37), Purification and application of isoflavones from soybeans as a substitute for treating women with postmenopausal symptoms. 30/06/2005 to 31/05/2009.
  4. PI, HK$149,000, University Grants Committee of Hong Kong-Continuous Learning & Improvement through Teaching Innovation (00386E). Bring a molecular cell biology laboratory into the classroom of HKUST. 1/11/2005 to 29/02/2008.
  5. PI, HK$50,000, University Grants Committee of Hong Kong-Continuous Learning & Improvement through Teaching Innovation (00407E), Hong Kong Bioinformatics in Bioengineering: Direct Experience with Interactive Learning. 06/12/2006 to 31/05/2008.
Patents
Granted (7)

  1. Luo KQ, Yu T, Luo HW, Acetyltanshinone IIA (ATA) as anticancer agent, China Patent No.: 201280028087.2, granted on Feb 3, 2016.
  2. Luo KQ, Yu T, Luo HW, Acetyltanshinone IIA (ATA) as anticancer agent. US Patent No.: US 9,226,912 B2, granted on Jan. 5, 2016.
  3. Luo KQ, Yu T, Luo HW, Acetyltanshinone IIA (ATA) as anticancer agent. Singapore Patent No. 193492, granted on August 15, 2014.
  4. Ng KM, Luo Q, Zhang EJ, Harjo B, A health care product containing isoflavone aglycones and method of preparing the same. US Patent No. US 7,553,505 B2, granted on June 30, 2009.
  5. Chang DC, Luo KQ, Nucleic Acid encoding fluorescent protein constructs and methods for detecting apoptosis. US Patent No. US 7,354,735, granted on April 8, 2008.
  6. Chang DC, Luo Q, Intra-molecular modification of GFP (green fluorescent protein) for detecting apoptosis and specific enzyme activity in living cells. US Patent No. US 7,049,400, granted on May 23, 2006.
  7. Chang DC, Luo KQ, GFP-based methods for detecting apoptosis. PRC Patent No. ZL 02 1 20427.6, granted on May 3, 2006.

Pending (5)

  1. Tang BZ, Ng KM, Luo Q, Yu Y, Hong YN, Liu JZ, Chen SJ, Lam WY, Wang Z, Qin W, Kwok TK, Aggregation Induced Emission of Fluorescent Bioprobes and Methods of Using the Same. US Patent Application No. 13/899,070, Filing Date: May 21, 2013, pending.
  2. Luo KQ and Xu JJ, Method of preparing a controlled release particle of soy isoflavone with non-biodegradable polymer using a supercritical fluid extraction of emulsion (SFEE) process. US Patent Application No.: 13/733,900, Filing date: January 4, 2013, pending.
  3. Luo KQ and Xu JJ, Method of preparing soy isoflavone nanoparticles by precipitation with compressed antisolvent (PCA) using a supercritical fluid. US Patent Application No.: 13/733,901, Filing date: January 4, 2013, pending.
  4. Zhang LJ, Ling L, Zhou LY, Wu ZM, Guo XD, Jiang W, Luo Q, Qian Y, pH-sensitive nanoparticles for oral insulin delivery. US Patent Application No. 13/561,106, Filed July 30, 2012, pending.
  5. Qian Y, Zhang LJ, Wu ZM, Zhou LY, Jiang W, Ling L, Luo Q, Guo XD, Enteric-coated capsule containing cationic nanoparticles for oral insulin delivery. US Patent Application No. 13/561,105, Filing Date: July 30, 2012, pending.
Awards
  1. The best poster award received during the International Symposium on Advances in Molecular Sensory Engineering (SAMSE), July 27-28, 2017, Singapore.
  2. The best poster award received during the 16th Biennial Metastasis Research Congress, Sep 16-20, 2016, Chengdu, China.
  3. The best poster award received during the International Conference of Optofluidics, July 26-29, 2015, Taipei, Taiwan.
  4. Travel Award received from the American Society for Cell Biology in Dec. 1993, San Francisco, USA.
Professional Activities
Membership
American Society for Cell Biology since 1993
Services to University of Macau

  1. Chair of Animal Research Ethics of UM (2016-present)
  2. Member of the UM Senate (2016-present)
  3. Research Committee of UM (2016-present)
  4. Equipment Committee of FHS and ICMS (2016-present)
  5. Faculty Executive Committee (FEC) (2016-present)
  6. Faculty Academic Personnel Committee (2017-present)
  7. Graduate Studies Committee (2016-present)
  8. Committee for Faculty Contract Renew (2016-present)
  9. Committee for Macau Fellow Selection (2016-present)
  10. Coordinator of Final Year Project (2016-present)

Services to Nanyang Technological University in Singapore

  1. Assistant Chair of SCBE for Students (2014-2015)
  2. Chairperson of Institutional Biosafety Committee (IBC) of NTU (2014-2015)
  3. Institutional Animal Care and Use Committee (IACUC) of NTU (2010-2015)
Services to International Scientific Communities

Editorial Board

  1. Editorial Board of Advances in Modern Oncology Research
  2. Editorial Board of AIMS Bioengineering
  3. Review Editor of Frontiers in Ethnopharmacology
  4. Editorial Board of Austin Chemical Engineering

Conference Committees

  1. Organizing Committee, 3rd World Conference on the Pharmacology of Natural and Traditional Medicine 2015, July 22-24, Singapore
  2. Technical Program Committee (TPC) for MicroTAS 2014, October 26-30, 2014, San Antonio, Texas, USA
  3. Coordinator of the NTU-SCBE Symposium on Drug Discovery, Drug Delivery and Regenerative Medicine at the 6th Annual BioPharma Asia Convention, March 19, 2013, Singapore
  4. Session Chair, The HKUST International Conference on Biomedical Engineering, Jan 10-12, 2013, Hong Kong
  5. Organizing Committee, 2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2), August 2010, Singapore
  6. Session Chair, International Conference on Recent Development in Chinese Herbal Medicine, January 2010, Singapore
  7. Organizing Committee, 7th International Conference of Modernization of Chinese Medicine & Health Products, August 2008, Hong Kong
  8. Organizing Committee, 6th International Conference of Modernization of Chinese Medicine & Health Products, August 2007, Hong Kong

Reviewer for Grant Applications

  1. European Research Council Consolidator Grant
  2. Medical Research Council of UK
  3. National Research Foundation of Singapore Competitive Research Programme
  4. Ministry of Education, Singapore, Academic Research Fund Tier 2
  5. Ministry of Education, Singapore, Academic Research Fund Tier 1
  6. Ministry of Education, Singapore, Translation and Innovation Fund
  7. Agency for Science, Technology and Research, Nanyang Technological University, and National Health Group Skin Research Grant
  8. Nanyang Technological University iFood Research Grant

Reviewer for International Journals (18)

Biotechnology Progress, Cancer Letters, Cancer Chemotherapy and Pharmacology, Chemical Engineering Research and Design, Current Medicinal Chemistry, Evidence-based Complementary and Alternative Medicine, Food and Bioprocess Technology, Industrial & Engineering Chemistry Research, Integrative Biology, International Journal of Pharmaceutics, Journal of Agricultural and Food Chemistry, Journal of the American Chemical Society, Journal of Food Biochemistry, Journal of Materials Chemistry, Phytotherapy Research, PLoS One, Separation and Purification Technology, Oncotarget.

Others
  1. Courses taught: Translational Medicine, Molecular Cell Biology, Advanced Cell Biology, Biochemistry for Bioengineering, Biomolecular Engineering, Biomedical Nanotechnology, Synthetic Biology and Bioinformatics, and Applications of Engineering in Life Sciences.
  2. Average teaching evaluation from 36 classes of 12 courses taught from 2004 to 2015: 90%.
  3. Supervised students and staff: 8 Postdocs, 21 Ph.D. students, 19 M.S. students, 8 research staff, and 53 undergraduate students.