Talk title Vibrational spectroscopy in life sciences: from cells to tissues
Speaker Dr. Valter Sergo
Professor, Department of Engineering and Architecture, University of Trieste, Italy
Date & Time 26 February 2018 (Monday) 15:00-16:00
Venue Room G004, E12 Building (University of Macau)
Abstract In latest years, the use of Raman Spectroscopy and Surface-Enhanced Raman spectroscopy (SERS) for Life Science applications has been growing considerably. Intrinsically, the Raman effect is label free and, as such, it does not introduce unwanted guests in the system under analysis; in a label-free Raman SERS approach, analytes (drugs, biomarkers, etc.) are put in contact with nanostructured metallic surfaces, (typically Au or Ag nanoparticles) generating a complex spectrum very rich in information. This fact, coupled with the rapidity of measurements and the ease of sample preparation, have paved the way for a wide spread use of these techniques in Life Sciences and in Medicine. In this seminar, after a brief introduction to the foundations of the technique and to the method for Raman Imaging, several cases of the advantageous use of the Raman effect in Life Science issues will be presented: 

  • Localization of Hemozoin inside single red blood cells infected with malaria (Plasmodium falciparum);
  • In-situ studies of oxidative stress in living organisms (tardigrades);
  • Raman Mapping of the cartilage tissues;
  • Raman mapping of Histological sections: CCAM disease, coeliac disease; and
  • Possibility of cancer screening through Raman/SERS spectroscopy.